Could Resveratrol protect against SARS-CoV-2?

A couple of weeks ago I came across some interesting research about Resveratrol. If you’re unsure what that is, I would recommend reading this page. A study was published in 2017 titled; Effective inhibition of MERS-CoV infection by resveratrol. MERS-CoV is a coronavirus, while it’s distinct from SARS coronavirus, it is in the same group. The study tests the possibility that Resveratrol could inhibit MERS-CoV from infecting cells. It was found to be useful and the conclusion of the study was that it could be a potential anti-MERS agent. This raises the question, could Resveratrol protect against SARS-CoV-2? In other words, the virus responsible for the current pandemic, COVID-19.

Can it fight SARS-CoV-2?

There’s not quite enough evidence to deem it beneficial in defeating MERS-CoV. Unfortunately, there is also no evidence for it working against coronaviruses in-vivo (humans & animals). The study was done in-vitro (tested on cells), which doesn’t exactly simulate a human or animal body. Resveratrol is thought to be beneficial for cellular health, although strong evidence is lacking. On the other hand, many of the studies done on it point out that it’s poorly bio-available. Resveratrol may be promising if bio-availability can be increased, as many in-vitro studies have shown it to be promising. Studies in mice also seem to be promising for treatment and prevention of several diseases. Don’t believe me? Take a look!

That begs the question, can it fight SARS-CoV-2? The answer is, maybe. If it can inhibit and prevent the infection of MERS-CoV in humans as it does in cells, it’s possible it can do the same against SARS-CoV-2 and prevent COVID-19.

Chemical structure of trans-resveratrol, the most active of Resveratrol.

Is it worth trying?

I think it is, if the bio-availability can be improved it could have a lot more potential. There needs to be more research done in humans as well (which is ongoing). I believe the failure of Resveratrol as a promising supplement or medication came from the failure of a company, Sirtuis Pharmaceuticals. Not only that, it is poorly bio-available in its standard form. It has received a bit of stigmatism as well, because of overly hopeful remarks made by some researchers. Overall, I believe it still has promise. It’s widely available for purchase and sometimes bundled with Quercetin and Nicotinamide Riboside. Just make sure you research the brand before trying.

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